Elucidating the structure
These new structural insights into SARM1 are expected to facilitate advances in drug design for diseases such as multiple sclerosis, amyotrophic lateral sclerosis, and peripheral neuropathies. Bostjan Kobe of The University of Queensland, with Disarm scientists, has described the crystal structure of two important protein domains of SARM1, specifically the sterile alpha motif (SAM) and the toll/interleukin-1 receptor (TIR) domains.
This advance makes possible the use of sophisticated computational tools to accelerate drug discovery via structure-based drug design, with far-reaching implications for drug development in neurodegenerative diseases.
In this paper, we analyze the asymptotic information-theoretic relative performance of Laplacian spectral embedding and adjacency spectral embedding for block assignment recovery in stochastic block model graphs by way of Chernoff information.